Structure function analysis

During the last 18 years Prof. Shoham’s group focused on the structure-functional analysis of glycoside hydrolases. This research is conducted in collaboration with Prof. Gil  Shoham at the Hebrew University.  They used an integrated approach that combines organic chemistry, X-ray crystallography and molecular biology to identify critically important aspects concerning the 3D structure, stability and catalytic properties of selected enzymes. These studies revealed the catalytic mechanism and the 3-D structure of several new glycoside hydrolyse families, and demonstrated the ability to convert their original activity (hydrolysis) towards glycosynthesis.

Structure function analysis